Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy.
Intern Med
; 53(18): 2165-70, 2014.
Article
en En
| MEDLINE
| ID: mdl-25224208
ABSTRACT
Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8(+) T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biopsia
/
Infecciones por VIH
/
Virus de la Hepatitis B
/
VIH
/
Síndrome Inflamatorio de Reconstitución Inmune
/
Hígado
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Intern Med
Asunto de la revista:
MEDICINA INTERNA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón