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Immune function assay (immunknow) drop over first 6 months after renal transplant: a predictor of opportunistic viral infections?
Quaglia, M; Cena, T; Fenoglio, R; Musetti, C; Cagna, D; Radin, E; Roggero, S; Amoroso, A; Magnani, C; Stratta, P.
Afiliación
  • Quaglia M; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy. Electronic address: marco.quaglia@gmail.com.
  • Cena T; Medical Statistics and Cancer Epidemiology Unit, "A. Avogadro" University, Novara, Italy.
  • Fenoglio R; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy.
  • Musetti C; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy.
  • Cagna D; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy.
  • Radin E; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy.
  • Roggero S; Transplantation Immunology Service, "San Giovanni Battista" University Hospital, Turin, Italy.
  • Amoroso A; Transplantation Immunology Service, "San Giovanni Battista" University Hospital, Turin, Italy.
  • Magnani C; Medical Statistics and Cancer Epidemiology Unit, "A. Avogadro" University, Novara, Italy.
  • Stratta P; Nephrology and Transplant Unit, Department of Translational Medicine, "Maggiore della Carità" University Hospital and Interdisciplinary Research Center Autoimmune Disease (IRCAD), "A. Avogadro" University, Novara, Italy.
Transplant Proc ; 46(7): 2220-3, 2014 Sep.
Article en En | MEDLINE | ID: mdl-25242755
ABSTRACT

BACKGROUND:

The Immuknow assay (IKA; Cylex) is a T-cell immune function assay that evaluates immunoreactivity in immunocompromised patients. The aim of this study was to analyze IKA values in a cohort of kidney transplantation (KT) recipients to investigate correlations between single-time point low IKA values and their trend over time with cytomegalovirus (CMV) or BK virus (BKV) reactivation.

METHODS:

A total of 118 adult patients receiving deceased-donor KT were enrolled (55.6±11.9 years old; 79 [66.9%] male). IKA CMV and BKV viremia determinations and were performed at months 1, 3, and 6 after surgery.

RESULTS:

Overall, 272 IKA determinations were performed IKA values significantly decreased from month 1 (422±184 ng/mL) to month 3 (330±159 ng/mL; P<.001) and from month 3 to month 6 (300±128 ng/mL; P=.030). IKA values did not correlate with renal function or viral reactivation at any time. However, patients with either CMV or BKV viremia had a trend to higher IKA values at month 1 and lower IKA values at month 6, even if the difference did not reach a statistical significance (P=.115).

CONCLUSIONS:

Our study suggests that presence of low immunologic reactivity (IKA<225 ng/mL) is not associated with an increased risk of CMV and BKV reactivation over the 1st 6 months after KT. However, a trend to a more pronounced drop in IKA values over time was observed in patients with viral reactivation. These preliminary results suggests that drop in IKA values within the 1st post-KT months, unlike single-time point immune function assay, may predict the risk of opportunistic viral infections.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Inmunológicas / Infecciones Oportunistas / Trasplante de Riñón / Infecciones por Citomegalovirus / Infecciones por Polyomavirus Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Inmunológicas / Infecciones Oportunistas / Trasplante de Riñón / Infecciones por Citomegalovirus / Infecciones por Polyomavirus Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article