An immunohistochemical study of angiokeratomas of children.
Am J Dermatopathol
; 36(10): 796-9, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-25243395
ABSTRACT
BACKGROUND:
Angiokeratomas are vascular anomalies in which the clinical, histological, and immunohistochemical characteristics are insufficient to determine whether the lesion is a vascular neoplasm or vascular malformation, and their exact origin is also uncertain. To further clarify the nosology of angiokeratomas, we studied 14 cases.OBJECTIVE:
To analyze immunohistochemical characteristics of angiokeratomas to gain further insight into its histogenesis.METHODS:
We carried out a retrospective review of the histopathology files. Immunohistochemical expression for Wilms tumor 1 (WT1), GLUT1, D2-40, podoplanin, Prox1, and ERG1 was performed in 14 cases.RESULTS:
None of the lesions showed cytoplasmic immunoreactivity for WT1. GLUT1 resulted to be negative in 13 cases. All 14 cases in our series showed some expression with at least 1 lymphatic marker. In 12 cases, the positivity was diffuse and strong for ERG1.CONCLUSIONS:
Angiokeratomas are complex lesions with difficult classification. Angiokeratomas are best considered vascular malformations in children, according to the WT1-negative stain. The lymphatic component of angiokeratoma is demonstrated by positivity and/or focal expression for lymphatic markers (podoplanin and Prox1); however, a blood capillary component within the malformation cannot be excluded.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Biomarcadores de Tumor
/
Vasos Linfáticos
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Angioqueratoma
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Am J Dermatopathol
Año:
2014
Tipo del documento:
Article
País de afiliación:
España