Carbapenem resistance in a human clinical isolate identified to be closely related to Acinetobacter indicus.

Bonnin, Rémy A; Poirel, Laurent; van der Reijden, Tanny J K; Dijkshoorn, Lenie; Lescat, Mathilde; Nordmann, Patrice

Bonnin, Rémy A; Poirel, Laurent; van der Reijden, Tanny J K; Dijkshoorn, Lenie; Lescat, Mathilde; Nordmann, Patrice.

Afiliación

Bonnin RA; INSERM U914 'Emerging Resistance to Antibiotics', K.-Bicêtre, France.
Poirel L; INSERM U914 'Emerging Resistance to Antibiotics', K.-Bicêtre, France; Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland. Electronic address: laurent.poirel@unifr.ch.
van der Reijden TJ; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Dijkshoorn L; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Lescat M; Service de Bactériologie-Virologie, Hôpital Avicenne, Bobigny, France.
Nordmann P; INSERM U914 'Emerging Resistance to Antibiotics', K.-Bicêtre, France; Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.

Int J Antimicrob Agents ; 44(4): 345-50, 2014 Oct.

Article en En | MEDLINE | ID: mdl-25245212

RESUMEN

Here we report a case of carbapenem resistance in a human clinical isolate that was found to be closely related to the newly described environmental species Acinetobacter indicus. This strain harboured the blaOXA-23 carbapenemase gene located on a conjugative plasmid. Partial sequencing of 16S rDNA and rpoB genes, together with matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) analysis, showed that this strain was distantly related to the Acinetobacter baumannii-calcoaceticus complex and was closely related to A. indicus.

Asunto(s)

Infecciones por Acinetobacter/microbiología; Acinetobacter/clasificación; Acinetobacter/efectos de los fármacos; Antibacterianos/farmacología; Carbapenémicos/farmacología; Resistencia betalactámica; Acinetobacter/química; Acinetobacter/aislamiento & purificación; Análisis por Conglomerados; ADN Bacteriano/química; ADN Bacteriano/genética; ADN Ribosómico/química; ADN Ribosómico/genética; ARN Polimerasas Dirigidas por ADN/genética; Humanos; Masculino; Datos de Secuencia Molecular; Filogenia; Plásmidos; ARN Ribosómico 16S/genética; Análisis de Secuencia de ADN; Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción; beta-Lactamasas/genética

Palabras clave

Acinetobacter; Carbapenemase; OXA-23; Taxonomy; ß-Lactamase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acinetobacter / Infecciones por Acinetobacter / Carbapenémicos / Resistencia betalactámica / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Int J Antimicrob Agents Año: 2014 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos

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