Toward the use of proxy reports for estimating long-term patient-reported outcomes in multiple sclerosis.
Mult Scler
; 21(14): 1865-71, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-25257617
ABSTRACT
BACKGROUND:
Assessment of disease impact in multiple sclerosis (MS) is usually driven by information obtained directly from patients using patient-reported outcomes. However, when patients' response in longitudinal studies is less reliable or missing, proxy respondents may be used.OBJECTIVE:
The objective of this paper is to evaluate whether long-term patient scores can be reliably estimated using scores obtained from proxies.METHODS:
Baseline, six-month and two-year data were collected from 155 patients and proxies on the physical scale of the Multiple Sclerosis Impact Scale (MSIS-29). Linear regression analyses were performed with the patient two-year scores as outcome, proxy two-year scores as predictor and other variables that could contribute to a better prediction of the patient follow-up score.RESULTS:
The patient follow-up score could be predicted rather accurately (R(2) = 0.74) using the patient baseline score and the proxy follow-up score. The correlation between observed and predicted scores was 0.86. The model performed well in different follow-up durations and even better in an external cohort.CONCLUSION:
A simple model of a constant value (intercept), the patient baseline score and the proxy follow-up score can predict patients' follow-up score on the physical impact of MS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Índice de Severidad de la Enfermedad
/
Evaluación de Resultado en la Atención de Salud
/
Progresión de la Enfermedad
/
Evaluación del Resultado de la Atención al Paciente
/
Esclerosis Múltiple
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Aspecto:
Patient_preference
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos