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Two new amides from a halotolerant fungus, Myrothecium sp. GS-17.
Liu, Tao; Zhang, Songya; Zhu, Jing; Pan, Huaqi; Bai, Jiao; Li, Zhanlin; Guan, Liping; Liu, Guyue; Yuan, Chunmao; Wu, Xin; Hua, Huiming.
Afiliación
  • Liu T; Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang, China.
  • Zhang S; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Zhu J; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China.
  • Pan H; Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China.
  • Bai J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Li Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Guan L; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Liu G; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
  • Yuan C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Wu X; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
  • Hua H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
J Antibiot (Tokyo) ; 68(4): 267-70, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25269461
ABSTRACT
Two new amides, named N-acetyl-2,4,10,17-tetrahydroxyheptadecylamine (1) and N-acetyl-3,5,11,18-tetrahydroxyoctadecyl-2-amine (2), were isolated from a halotolerant fungus, Myrothecium sp. GS-17. Their structures were identified on the basis of spectroscopic characteristics. The cancer cell cytotoxicities of two compounds were evaluated, and compound 2 exhibited weak cytotoxicity in HL-60 cell line.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Alcoholes Grasos / Hypocreales / Acetamidas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Antibiot (Tokyo) Año: 2015 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Alcoholes Grasos / Hypocreales / Acetamidas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Antibiot (Tokyo) Año: 2015 Tipo del documento: Article País de afiliación: China