Results of a cohort of 200 hormone-naïve consecutive patients with prostate cancer treated with iodine 125 permanent interstitial brachytherapy by the same multidisciplinary team.
Cancer Radiother
; 18(7): 643-8, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25286905
ABSTRACT
PURPOSE:
To report survival and morbidity of a cohort of 200 hormone-naïve consecutive patients with localized prostate cancer, treated by low-dose rate brachytherapy within the frame of multidisciplinary approach. PATIENTS ANDMETHODS:
Between 2001 and 2011, 200 patients were treated by the same team with 125 iodine seeds 167 low-risk and 33 intermediate risk according to the d'Amico classification; eligible patients had clinical stage T1/T2a-b, Gleason score 3+3 or 3+4, baseline prostate-specific antigen level below 15ng/mL, prostate volume less than 60cm(3). The median number of random biopsies was 12 (range 6-32) and the breakdown of positive cores was as follows 1 (29%), 2 (35%), 3 or more (36%). Acute morbidity was assessed according to the Common Terminology Criteria for Adverse Events and late toxicity according to the EORTC/RTOG scale. Data were prospectively collected.RESULTS:
The median follow-up was 69 months (range 16 to 135). The 5- and 10-year biochemical relapse free survivals were 95.6% (95% confidence interval [CI] 91-98) and 89.7% (95% CI 79.4-95.0). The 5-year and 10-year overall survival were respectively 96.4% (95% CI 92-98.4) and 89.7% (95% CI 80.8-94.6%) and the 10-year disease specific survival, 99.1% (95% CI 93.0-99.9). The 5- and 10-year grade 3 acute toxicity cumulative rate were respectively 3.3% (95% CI 1.4-6.6) and 4% (95% CI 1.4-6.6) and the 5- and 10-year grades 3 cumulative late toxicity 2.5% (95% CI 2.0-5.9) and 4% (95% CI 2.0-5.9).CONCLUSION:
Brachytherapy managed within the frame of a multidisciplinary approach - from diagnosis to evaluation - may offer optimized results with a reduced late toxicity rate, while remaining opened to dosimetry and technical improvements.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Grupo de Atención al Paciente
/
Neoplasias de la Próstata
/
Braquiterapia
/
Radioisótopos de Yodo
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Cancer Radiother
Asunto de la revista:
NEOPLASIAS
/
RADIOTERAPIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia