Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML.

Zaitseva, Lyubov; Murray, Megan Y; Shafat, Manar S; Lawes, Matthew J; MacEwan, David J; Bowles, Kristian M; Rushworth, Stuart A

Zaitseva, Lyubov; Murray, Megan Y; Shafat, Manar S; Lawes, Matthew J; MacEwan, David J; Bowles, Kristian M; Rushworth, Stuart A.

Afiliación

Zaitseva L; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Murray MY; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Shafat MS; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Lawes MJ; Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich United Kingdom.
MacEwan DJ; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Bowles KM; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom. Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich United Kingdom.
Rushworth SA; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.

Oncotarget ; 5(20): 9930-8, 2014 Oct 30.

Article en En | MEDLINE | ID: mdl-25294819

Asunto(s)

Quimiocina CXCL12/antagonistas & inhibidores; Leucemia Mieloide Aguda/tratamiento farmacológico; Proteínas Tirosina Quinasas/antagonistas & inhibidores; Pirazoles/farmacología; Pirimidinas/farmacología; Adenina/análogos & derivados; Adulto; Agammaglobulinemia Tirosina Quinasa; Anciano; Anciano de 80 o más Años; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Quimiocina CXCL12/metabolismo; Femenino; Técnicas de Silenciamiento del Gen; Humanos; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/patología; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Masculino; Persona de Mediana Edad; Piperidinas; Proteínas Tirosina Quinasas/genética; Proteínas Tirosina Quinasas/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Proteínas Tirosina Quinasas / Leucemia Mieloide Aguda / Quimiocina CXCL12 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido

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