Growth hormone, insulin-like growth factor-1 and the aging brain.
Exp Gerontol
; 68: 76-81, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25300732
ABSTRACT
Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and function of cells throughout the body. Several clinical diseases that result in a decline in physical and mental functions are marked by mutations that disrupt GH or IGF-1 signaling. During the lifespan there is a robust decrease in both GH and IGF-1. Because GH and IGF-1 are master regulators of cellular function, impaired GH and IGF-1 signaling in aging/disease states leads to significant alterations in tissue structure and function, especially within the brain. This review is intended to highlight the effects of the GH and IGF-1 on neuronal structure, function, and plasticity. Furthermore, we address several potential mechanisms through which the age-related reductions in GH and IGF-1 affect cognition. Together, the studies reviewed here highlight the importance of maintaining GH and IGF-1 signaling in order to sustain proper brain function throughout the lifespan.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Envejecimiento
/
Factor I del Crecimiento Similar a la Insulina
/
Hormona del Crecimiento
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Animals
/
Child
/
Humans
Idioma:
En
Revista:
Exp Gerontol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos