Your browser doesn't support javascript.
loading
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
Kiryluk, Krzysztof; Li, Yifu; Scolari, Francesco; Sanna-Cherchi, Simone; Choi, Murim; Verbitsky, Miguel; Fasel, David; Lata, Sneh; Prakash, Sindhuri; Shapiro, Samantha; Fischman, Clara; Snyder, Holly J; Appel, Gerald; Izzi, Claudia; Viola, Battista Fabio; Dallera, Nadia; Del Vecchio, Lucia; Barlassina, Cristina; Salvi, Erika; Bertinetto, Francesca Eleonora; Amoroso, Antonio; Savoldi, Silvana; Rocchietti, Marcella; Amore, Alessandro; Peruzzi, Licia; Coppo, Rosanna; Salvadori, Maurizio; Ravani, Pietro; Magistroni, Riccardo; Ghiggeri, Gian Marco; Caridi, Gianluca; Bodria, Monica; Lugani, Francesca; Allegri, Landino; Delsante, Marco; Maiorana, Mariarosa; Magnano, Andrea; Frasca, Giovanni; Boer, Emanuela; Boscutti, Giuliano; Ponticelli, Claudio; Mignani, Renzo; Marcantoni, Carmelita; Di Landro, Domenico; Santoro, Domenico; Pani, Antonello; Polci, Rosaria; Feriozzi, Sandro; Chicca, Silvana; Galliani, Marco.
Afiliación
  • Kiryluk K; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Li Y; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Scolari F; 1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Department of Medical and Surgical Specialties, Radiological Sciences, University of Brescia, Brescia, Italy.
  • Sanna-Cherchi S; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Choi M; 1] Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
  • Verbitsky M; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Fasel D; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Lata S; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Prakash S; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Shapiro S; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Fischman C; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Snyder HJ; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Appel G; Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Izzi C; 1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.
  • Viola BF; Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
  • Dallera N; 1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Department of Medical and Surgical Specialties, Radiological Sciences, University of Brescia, Brescia, Italy.
  • Del Vecchio L; Renal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
  • Barlassina C; Renal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
  • Salvi E; Renal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
  • Bertinetto FE; 1] Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, Turin, Italy. [2] Medical Genetics, Department of Medical Sciences, University of Torino, Turin, Italy.
  • Amoroso A; 1] Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, Turin, Italy. [2] Medical Genetics, Department of Medical Sciences, University of Torino, Turin, Italy.
  • Savoldi S; Nephrology and Dialysis Unit, Ospedali di Cirié e Chivasso, Cirié, Turin, Italy.
  • Rocchietti M; Nephrology and Dialysis Unit, Ospedali di Cirié e Chivasso, Cirié, Turin, Italy.
  • Amore A; Nephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
  • Peruzzi L; Nephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
  • Coppo R; Nephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
  • Salvadori M; Division of Nephrology and Renal Transplantation, Carreggi Hospital, Florence, Italy.
  • Ravani P; 1] Department of Medicine, University of Calgary, Calgary, Alberta, Canada. [2] Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
  • Magistroni R; Division of Nephrology Dialysis and Transplantation, Azienda Ospedaliero Universitaria Policlinico di Modena, Università di Modena e Reggio Emilia, Modena, Italy.
  • Ghiggeri GM; Division of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
  • Caridi G; Division of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
  • Bodria M; Division of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
  • Lugani F; Division of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
  • Allegri L; 1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
  • Delsante M; 1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
  • Maiorana M; 1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
  • Magnano A; 1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
  • Frasca G; Division of Nephrology, Dialysis and Renal Transplantation, Riuniti Hospital, Ancona, Italy.
  • Boer E; Division of Nephrology and Dialysis, Gorizia Hospital, Gorizia, Italy.
  • Boscutti G; Division of Nephrology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Trieste, Italy.
  • Ponticelli C; Nephrology and Dialysis Unit, Humanitas Clinical and Research Center, Milan, Italy.
  • Mignani R; Division of Nephrology and Dialysis, Infermi Hospital, Rimini, Italy.
  • Marcantoni C; Division of Nephrology, Cannizzaro Hospital, Catania, Italy.
  • Di Landro D; Division of Nephrology, Cannizzaro Hospital, Catania, Italy.
  • Santoro D; Chair of Nephrology, Division of Nephology and Dialysis, University of Messina, Azienda Ospedaliero-Universitaria Policlinico, Messina, Italy.
  • Pani A; Department of Nephrology and Dialysis, G. Brotzu Hospital, Cagliari, Italy.
  • Polci R; Nephrology and Dialysis, Hospital of Viterbo, Viterbo, Italy.
  • Feriozzi S; Nephrology and Dialysis, Hospital of Viterbo, Viterbo, Italy.
  • Chicca S; Division of Nephrology and Dialysis, Sandro Pertini Hospital, Rome, Italy.
  • Galliani M; Division of Nephrology and Dialysis, Sandro Pertini Hospital, Rome, Italy.
Nat Genet ; 46(11): 1187-96, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25305756
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos HLA-D / Antígeno CD11b / Proteínas Proto-Oncogénicas c-vav / Proteínas Adaptadoras de Señalización CARD / Sitios Genéticos / Glomerulonefritis por IGA / Inmunidad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos HLA-D / Antígeno CD11b / Proteínas Proto-Oncogénicas c-vav / Proteínas Adaptadoras de Señalización CARD / Sitios Genéticos / Glomerulonefritis por IGA / Inmunidad Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos