Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection.
World J Gastrointest Oncol
; 6(10): 413-9, 2014 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-25320658
ABSTRACT
AIM:
To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer (CRC) and benign patients and postoperatively after CRC resection.METHODS:
A plasma bank was screened for minimally invasive colorectal cancer resection (MICR) for CRC and benign disease (BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples (postoperative day 7-27) were available. Monocyte chemotactic protein-1 (MCP-1) levels (pg/mL) were determined via enzyme linked immuno-absorbent assay.RESULTS:
One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level (283.1, CI 256.0, 294.3) was higher than the BEN group level (227.5, CI 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1 (446.3, CI 418.0, 520.1), postoperative day 3 (342.7, CI 320.4, 377.4), postoperative day 7-13 (326.5, CI 299.4, 354.1), postoperative day 14-20 (361.6, CI 287.8, 407.9), and postoperative day 21-27 (318.1, CI 287.2, 371.6; P < 0.001 for all).CONCLUSION:
Preoperative MCP-1 levels were higher in CRC patients (vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
World J Gastrointest Oncol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos