Asymmetric hydrogenation via capture of active intermediates generated from aza-Pinacol rearrangement.
J Am Chem Soc
; 136(45): 15837-40, 2014 Nov 12.
Article
en En
| MEDLINE
| ID: mdl-25354228
ABSTRACT
An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Compuestos Aza
Idioma:
En
Revista:
J Am Chem Soc
Año:
2014
Tipo del documento:
Article
País de afiliación:
China