Nuclear actin activates human transcription factor genes including the OCT4 gene.
Biosci Biotechnol Biochem
; 79(2): 242-6, 2015.
Article
en En
| MEDLINE
| ID: mdl-25355676
ABSTRACT
RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación Transcripcional
/
Núcleo Celular
/
Actinas
/
Factor 3 de Transcripción de Unión a Octámeros
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón