Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling.
J Cell Sci
; 128(1): 33-9, 2015 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-25380820
ABSTRACT
Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/ß-catenin signalling that promote degradation of ß-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of ß-catenin by conductin is only poorly blocked by Dvl2. We propose that insensitivity to Dvl is an important feature of the role of conductin as a negative-feedback regulator of Wnt signalling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Proteínas Adaptadoras Transductoras de Señales
/
Proteína Axina
/
Vía de Señalización Wnt
Límite:
Humans
Idioma:
En
Revista:
J Cell Sci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania