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SIN3A mutations are rare in men with azoospermia.
Miyamoto, T; Koh, E; Tsujimura, A; Miyagawa, Y; Minase, G; Ueda, Y; Namiki, M; Sengoku, K.
Afiliación
  • Miyamoto T; Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
  • Koh E; Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
  • Tsujimura A; Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Miyagawa Y; Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Minase G; Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
  • Ueda Y; Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
  • Namiki M; Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
  • Sengoku K; Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
Andrologia ; 47(9): 1083-5, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25395209
ABSTRACT
A loss of function of the murine Sin3A gene resulted in male infertility with Sertoli cell-only syndrome (SCOS) phenotype in mice. Here, we investigated the relevance of this gene to human male infertility with azoospermia caused by SCOS. Mutation analysis of SIN3A in the coding region was performed on 80 Japanese patients. However, no variants could be detected. This study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by SCOS in humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Azoospermia / Síndrome de Sólo Células de Sertoli Límite: Adult / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Andrologia Año: 2015 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Azoospermia / Síndrome de Sólo Células de Sertoli Límite: Adult / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Andrologia Año: 2015 Tipo del documento: Article País de afiliación: Japón