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Diagnostic challenges of single plaque-like lesion paucibacillary leprosy.
Mem Inst Oswaldo Cruz ; 109(7): 944-7, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25411000
ABSTRACT
The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Piel / ADN Bacteriano / Lepra Paucibacilar / Mycobacterium leprae Aspecto clínico: Diagnóstico Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Mem Inst Oswaldo Cruz Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil