Mitochondrial DNA Haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
Mitochondrial DNA A DNA Mapp Seq Anal
; 27(3): 2221-4, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-25431816
ABSTRACT
The acquired immunodeficiency syndrome (AIDS) in humans was one of the chronic infections caused by human immunodeficiency virus (HIV), and the interactions between viral infection and mitochondrial energetic implicated that mitochondrial DNA (mtDNA) variation(s) may effect genetic susceptibility to AIDS. Thus, to illustrate the maternal genetic structure and further identify whether mtDNA variation(s) can effect HIV infection among southwest Chinese AIDS group, the whole mtDNA control region sequences of 70 AIDS patients and 480 health individuals from southwest China were analyzed here. Our results indicated the plausible recent genetic admixture results of AIDS group; comparison of matrilineal components between AIDS and matched Han groups showed that mtDNA haplogroup A (p = 0.048, OR = 3.006, 95% CI = 1.109-8.145) has a significant higher difference between the two groups; further comparison illustrated that mtDNA mutations 16,209 (p = 0.046, OR = 2.607, 95% CI = 0.988-6.876) and 16,319 (p = 0.009, OR = 2.965, 95% CI = 1.278-6.876) have significant differences between AIDS and matched control groups, and both of which were the defining variations of mtDNA haplogroup A, they further confirmed that mtDNA haplogroup A may confer genetic susceptibility to AIDS. Our results suggested that haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Infecciones por VIH
/
Síndrome de Inmunodeficiencia Adquirida
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
Tipo de estudio:
Etiology_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mitochondrial DNA A DNA Mapp Seq Anal
Año:
2016
Tipo del documento:
Article
País de afiliación:
China