Methylation of the FGFR2 gene is associated with high birth weight centile in humans.
Epigenomics
; 6(5): 477-91, 2014.
Article
en En
| MEDLINE
| ID: mdl-25431941
ABSTRACT
AIMS:
This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. MATERIALS &METHODS:
Using HumanMethylation450 arrays, we examined candidate gene-associated CpGs in cord blood from newborns with low (<15th centile), medium (40-60th centile) and high (>85th centile) BWC (n = 12). Candidates were examined in an investigation cohort (n = 110) using pyrosequencing and genotyping for putative methylation-associated polymorphisms performed using standard PCR.RESULTS:
Array analysis identified 314 candidate genes associated with BWC extremes, four of which showed ≥ 4 BWC-linked CpGs. Of these, PM20D1 and MI886 suggested genetically determined methylation levels. However, methylation at three CpGs in FGFR2 remained significantly associated with high BWC (p = 0.004-0.027).CONCLUSION:
We identified a novel biologically plausible candidate (FGFR2) for with BWC that merits further study.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peso al Nacer
/
Metilación de ADN
/
Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos
/
Estudios de Asociación Genética
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
Epigenomics
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido