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Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß.
Kick, Ellen; Martin, Richard; Xie, Yinong; Flatt, Brenton; Schweiger, Edwin; Wang, Tie-Lin; Busch, Brett; Nyman, Michael; Gu, Xiao-Hui; Yan, Grace; Wagner, Brandee; Nanao, Max; Nguyen, Lam; Stout, Thomas; Plonowski, Artur; Schulman, Ira; Ostrowski, Jacek; Kirchgessner, Todd; Wexler, Ruth; Mohan, Raju.
Afiliación
  • Kick E; Discovery Chemistry, Research & Development, Bristol-Myers Squibb, PO Box 5400, Princeton, NJ 08543-5400, United States. Electronic address: ellen.kick@bms.com.
  • Martin R; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Xie Y; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Flatt B; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Schweiger E; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Wang TL; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Busch B; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Nyman M; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Gu XH; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Yan G; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Wagner B; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Nanao M; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Nguyen L; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Stout T; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Plonowski A; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Schulman I; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
  • Ostrowski J; Cardiovascular Biology, Research & Development, Bristol-Myers Squibb, PO Box 5400, Princeton, NJ 08543-5400, United States.
  • Kirchgessner T; Cardiovascular Biology, Research & Development, Bristol-Myers Squibb, PO Box 5400, Princeton, NJ 08543-5400, United States.
  • Wexler R; Discovery Chemistry, Research & Development, Bristol-Myers Squibb, PO Box 5400, Princeton, NJ 08543-5400, United States.
  • Mohan R; Exelixis Inc, 210 East Grand Avenue, So. San Francisco, CA 94080, United States.
Bioorg Med Chem Lett ; 25(2): 372-7, 2015 Jan 15.
Article en En | MEDLINE | ID: mdl-25435151
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Sulfonas / Receptores Nucleares Huérfanos / Transportador 1 de Casete de Unión a ATP / Imidazoles / Hígado Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Sulfonas / Receptores Nucleares Huérfanos / Transportador 1 de Casete de Unión a ATP / Imidazoles / Hígado Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido