Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.

Rodger, Ian; Lam, Isabel; Purssell, Elizabeth; Thompson, Mesha; Rutter, Allison; Ozolins, Terence Rs

Rodger, Ian; Lam, Isabel; Purssell, Elizabeth; Thompson, Mesha; Rutter, Allison; Ozolins, Terence Rs.

Afiliación

Rodger I; Faculty of Medicine and Dentistry, University of Alberta, Edmonton AB T6G 2R7, Canada. Electronic address: irodger@ualberta.ca.
Lam I; Department of Biomedical and Molecular Sciences, Queen's University, Kingston ON K7L 3N6, Canada. Electronic address: isabel.lam@queensu.ca.
Purssell E; Faculty of Medicine, The University of British Columbia, Vancouver BC V6 T 1Z3, Canada. Electronic address: elizabeth.purssell@gmail.com.
Thompson M; Analytical Services Unit, Queen's University, Kingston ON K7L 3N6, Canada. Electronic address: thompson.mesha@queensu.ca.
Rutter A; Analytical Services Unit, Queen's University, Kingston ON K7L 3N6, Canada. Electronic address: ruttera@queensu.ca.
Ozolins TR; Department of Biomedical and Molecular Sciences, Queen's University, Kingston ON K7L 3N6, Canada. Electronic address: ozolinst@queensu.ca.

Toxicology ; 326: 142-52, 2014 Dec 04.

Article en En | MEDLINE | ID: mdl-25446330

Asunto(s)

Anomalías Inducidas por Medicamentos/etiología; Anticonvulsivantes/toxicidad; Dimetadiona/toxicidad; Cardiopatías Congénitas/inducido químicamente; Exposición Materna/efectos adversos; Alveolos Pulmonares/efectos de los fármacos; Anomalías Inducidas por Medicamentos/sangre; Animales; Anticonvulsivantes/sangre; Biomarcadores/sangre; Dimetadiona/sangre; Femenino; Peso Fetal/efectos de los fármacos; Edad Gestacional; Cardiopatías Congénitas/sangre; Embarazo; Alveolos Pulmonares/embriología; Alveolos Pulmonares/fisiopatología; Ratas Sprague-Dawley; Esternón/anomalías; Esternón/efectos de los fármacos

Palabras clave

Alveolar development; Anticonvulsant; Congenital heart defect; Dimethadione; Lung

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Anomalías Inducidas por Medicamentos / Exposición Materna / Dimetadiona / Cardiopatías Congénitas / Anticonvulsivantes Tipo de estudio: Diagnostic_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Toxicology Año: 2014 Tipo del documento: Article

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