Sense and specificity in neuronal calcium signalling.
Biochim Biophys Acta
; 1853(9): 1921-32, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-25447549
ABSTRACT
Changes in the intracellular free calcium concentration ([Ca²âº]i) in neurons regulate many and varied aspects of neuronal function over time scales from microseconds to days. The mystery is how a single signalling ion can lead to such diverse and specific changes in cell function. This is partly due to aspects of the Ca²âº signal itself, including its magnitude, duration, localisation and persistent or oscillatory nature. The transduction of the Ca²âº signal requires Ca²âºbinding to various Ca²âº sensor proteins. The different properties of these sensors are important for differential signal processing and determine the physiological specificity of Ca(2+) signalling pathways. A major factor underlying the specific roles of particular Ca²âº sensor proteins is the nature of their interaction with target proteins and how this mediates unique patterns of regulation. We review here recent progress from structural analyses and from functional analyses in model organisms that have begun to reveal the rules that underlie Ca²âº sensor protein specificity for target interaction. We discuss three case studies exemplifying different aspects of Ca²âº sensor/target interaction. This article is part of a special issue titled the 13th European Symposium on Calcium.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcio
/
Señalización del Calcio
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
2015
Tipo del documento:
Article