Synthesis and biological evaluation of nandrolone-bodipy conjugates.
Steroids
; 97: 62-6, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25448362
Here, we report synthesis and biological evaluation of fluorescent nandrolone-3-carboxymethyloxime derivatives conjugated with green-emitting bodipy dye via PEG linkers. All the newly-synthesized compounds were evaluated for their effect on cell proliferation in vitro in MCF-7, LNCaP, PC-3 and HEK 293T model cell lines using WST-1 assay. By means of live-cell fluorescence microscopy, the intracellular localization of nandrolone-bodipy conjugates was revealed in endoplasmic reticulum. Moreover, we performed competitive localization study with nonfluorescent nandrolone, metandrolone, boldenone, trenbolone, and testosterone.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Nandrolona
Límite:
Humans
Idioma:
En
Revista:
Steroids
Año:
2015
Tipo del documento:
Article
País de afiliación:
República Checa
Pais de publicación:
Estados Unidos