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Beyond autonomic neuromodulation: acetylcholinesterase inhibitor against peripheral artery disease.
Hao, Chang-Ning; Shi, Yi-Qin; Cheng, Ze-En; Cheng, Xianwu.
Afiliación
  • Hao CN; Department of Vascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: gilberthaocn@163.com.
  • Shi YQ; Department of Vascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Cheng ZE; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Cheng X; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Cardiology, Yanbian University School of Medicine, Yanji, China. Electronic address: xianwu@med.nagoya-u.ac.jp.
Int J Cardiol ; 178: 253-5, 2015 Jan 15.
Article en En | MEDLINE | ID: mdl-25464264
ABSTRACT
The acetylcholinesterase inhibitor (AChEI)-based therapeutic strategies have been shown to have vasculoprotective properties in the animal model of hindlimb ischemia due to its activation of the endothelial cholinergic system. However, little is know about whether other cell types (myocytes, immunocytes) are involved in the AChEI-related therapeutic benefits in peripheral artery disease. Therefore, we review the multiple cell-targeted effects of AChEI on the animal model of hindlimb ischemia and explore its clinical application in angiomyogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Colinesterasa / Enfermedad Arterial Periférica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Cardiol Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Colinesterasa / Enfermedad Arterial Periférica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Cardiol Año: 2015 Tipo del documento: Article