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Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.
Fedorova, Olga V; Lakatta, Edward G; Bagrov, Alexei Y; Melander, Olle.
Afiliación
  • Fedorova OV; aLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA bDepartment of Clinical Sciences, Lund University cDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
J Hypertens ; 33(3): 534-41; discussion 541, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25479026
OBJECTIVE: Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity. METHODS: Thirty-nine healthy individuals (53 ±â€Š11 years old; 20 men and 19 women) had a total daily NaCl intake of 50 mmol (low-salt) and 150 mmol (high-salt) for 4 weeks each, in a random order. ABP and MBG in plasma and urine were measured at baseline (unstandardized salt intake) and after high and low-salt intake. RESULTS: At baseline, plasma MBG (P-MBG) was related to 24-h SBP (r = 0.43, P = 0.007) and DBP (r = 0.32, P = 0.047), whereas 24-h urinary excretion of MBG (UE-MBG) was related to 24-h DBP only (r = 0.42, P = 0.008). Sex-specific analyses revealed that these relationships were significant in men only. Compared with low-salt, high-salt diet increased P-MBG (P = 0.029), mainly driven by results in men. Male P-MBG responders vs. nonresponders (above vs. below median of high-salt induced P-MBG increase) had markedly enhanced SBP (10.4 ±â€Š6.4 vs. 1.0 ±â€Š6.0 mmHg; P = 0.003) and DBP (6.7 ±â€Š5.0 vs. -0.6 ±â€Š3.6 mmHg; P = 0.001) salt sensitivity. CONCLUSION: In men, MBG increases with 24-h ABP, and similar to Dahl salt-sensitive rats, 4 weeks of high-salt induced MBG response is accompanied by marked salt sensitivity. However, these patterns seem to be sex-specific and are not observed in women.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Bufanólidos / Cloruro de Sodio Dietético / Hipertensión Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Hypertens Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Bufanólidos / Cloruro de Sodio Dietético / Hipertensión Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Hypertens Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos