The role of proteases in regulating Eph/ephrin signaling.
Cell Adh Migr
; 8(4): 294-307, 2014.
Article
en En
| MEDLINE
| ID: mdl-25482632
ABSTRACT
Proteases regulate a myriad of cell functions, both in normal and disease states. In addition to protein turnover, they regulate a range of signaling processes, including those mediated by Eph receptors and their ephrin ligands. A variety of proteases is reported to directly cleave Ephs and/or ephrins under different conditions, to promote receptor and/or ligand shedding, and regulate receptor/ligand internalisation and signaling. They also cleave other adhesion proteins in response to Eph-ephrin interactions, to indirectly facilitate Eph-mediated functions. Proteases thus contribute to Eph/ephrin mediated changes in cell-cell and cell-matrix interactions, in cell morphology and in cell migration and invasion, in a manner which appears to be tightly regulated by, and co-ordinated with, Eph signaling. This review summarizes the current literature describing the function and regulation of protease activities during Eph/ephrin-mediated cell signaling.
Palabras clave
AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, Amyloid precursor protein; Arf1, ADP rybosylation factor 1; BACE, ß-site APP cleaving enzyme; CAM, cell adhesion molecules; CTF, cytoplasmic fragment; CNC, cranial neural crest; ECM,; ADAM; Eph receptor tyrosine kinase; MMP; ephrin signaling; protease; γ-secretase
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Hidrolasas
/
Transducción de Señal
/
Movimiento Celular
/
Receptores de la Familia Eph
/
Efrinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Adh Migr
Año:
2014
Tipo del documento:
Article