Myasthenia gravis and related disorders: Pathology and molecular pathogenesis.
Biochim Biophys Acta
; 1852(4): 651-7, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25486268
ABSTRACT
Disorders affecting the presynaptic, synaptic, and postsynaptic portions of the neuromuscular junction arise from various mechanisms in children and adults, including acquired autoimmune or toxic processes as well as genetic mutations. Disorders include autoimmune myasthenia gravis associated with acetylcholine receptor, muscle specific kinase or Lrp4 antibodies, Lambert-Eaton myasthenic syndrome, nerve terminal hyperexcitability syndromes, Guillain Barré syndrome, botulism, organophosphate poisoning and a number of congenital myasthenic syndromes. This review focuses on the various molecular and pathophysiological mechanisms of these disorders, characterization of which has been crucial to the development of treatment strategies specific for each pathogenic mechanism. In the future, further understanding of the underlying processes may lead to more effective and targeted therapies of these disorders. This article is part of a Special Issue entitled Neuromuscular Diseases Pathology and Molecular Pathogenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Botulismo
/
Síndrome Miasténico de Lambert-Eaton
/
Síndrome de Guillain-Barré
/
Intoxicación por Organofosfatos
/
Miastenia Gravis
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos