Fasting levels of hepatic p-S6 are increased in old mice.
Cell Cycle
; 13(17): 2656-9, 2014.
Article
en En
| MEDLINE
| ID: mdl-25486351
ABSTRACT
TOR is involved in aging in a wide range of species from yeast to mammals. Here we show that, after overnight fasting, mTOR activity is higher in the livers of 28 months old female mice compared with middle-aged mice. Taken together with previous reports, our data predict that the life-extending effect of calorie restriction (CR) may be diminished, if CR is started in very old age. In contrast, rapamycin is known to be effective, even when started late in life.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Ayuno
/
Serina-Treonina Quinasas TOR
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Cell Cycle
Año:
2014
Tipo del documento:
Article