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Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion.
Warita, Katsuhiko; Warita, Tomoko; Beckwitt, Colin H; Schurdak, Mark E; Vazquez, Alexei; Wells, Alan; Oltvai, Zoltán N.
Afiliación
  • Warita K; Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
  • Warita T; Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
  • Beckwitt CH; Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
  • Schurdak ME; 1] Department of Computational &Systems Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA [2] University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA.
  • Vazquez A; Department of Radiation Oncology and Center for Systems Biology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA.
  • Wells A; Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
  • Oltvai ZN; 1] Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA [2] Department of Computational &Systems Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA.
Sci Rep ; 4: 7593, 2014 Dec 23.
Article en En | MEDLINE | ID: mdl-25534349
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Regulación Neoplásica de la Expresión Génica / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Proliferación Celular / Transición Epitelial-Mesenquimal / Ácido Mevalónico / Proteínas de Neoplasias / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Regulación Neoplásica de la Expresión Génica / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Proliferación Celular / Transición Epitelial-Mesenquimal / Ácido Mevalónico / Proteínas de Neoplasias / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido