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Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Clough, Emily; Jimenez, Erin; Kim, Yoo-Ah; Whitworth, Cale; Neville, Megan C; Hempel, Leonie U; Pavlou, Hania J; Chen, Zhen-Xia; Sturgill, David; Dale, Ryan K; Smith, Harold E; Przytycka, Teresa M; Goodwin, Stephen F; Van Doren, Mark; Oliver, Brian.
Afiliación
  • Clough E; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Jimenez E; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Kim YA; Computational Biology Branch, NCBI, NLM, NIH, Bethesda, MD 20814, USA.
  • Whitworth C; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: cale.whitworth@nih.gov.
  • Neville MC; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK.
  • Hempel LU; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Pavlou HJ; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK.
  • Chen ZX; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Sturgill D; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Dale RK; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Smith HE; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
  • Przytycka TM; Computational Biology Branch, NCBI, NLM, NIH, Bethesda, MD 20814, USA.
  • Goodwin SF; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK.
  • Van Doren M; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Oliver B; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Dev Cell ; 31(6): 761-73, 2014 Dec 22.
Article en En | MEDLINE | ID: mdl-25535918
ABSTRACT
Primary sex-determination "switches" evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind different targets, or how DSX proteins direct different outcomes in diverse tissues. We undertook genome-wide analyses to identify DSX targets using in vivo occupancy, binding site prediction, and evolutionary conservation. We find that DSX(F) and DSX(M) bind thousands of the same targets in multiple tissues in both sexes, yet these targets have sex- and tissue-specific functions. Interestingly, DSX targets show considerable overlap with targets identified for mouse DMRT1. DSX targets include transcription factors and signaling pathway components providing for direct and indirect regulation of sex-biased expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Proteínas de Drosophila / Proteínas de Unión al ADN / Drosophila melanogaster Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Proteínas de Drosophila / Proteínas de Unión al ADN / Drosophila melanogaster Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos