A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for &#945;9ß1 integrin is involved in the anti-type II collagen antibody-induced arthritis.

Kon, Shigeyuki; Nakayama, Yosuke; Matsumoto, Naoki; Ito, Koyu; Kanayama, Masashi; Kimura, Chiemi; Kouro, Hitomi; Ashitomi, Dai; Matsuda, Tadashi; Uede, Toshimitsu

A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9ß1 integrin is involved in the anti-type II collagen antibody-induced arthritis.

Kon, Shigeyuki; Nakayama, Yosuke; Matsumoto, Naoki; Ito, Koyu; Kanayama, Masashi; Kimura, Chiemi; Kouro, Hitomi; Ashitomi, Dai; Matsuda, Tadashi; Uede, Toshimitsu.

Afiliación

Kon S; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Nakayama Y; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Matsumoto N; Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Ito K; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Kanayama M; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Kimura C; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Kouro H; Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Ashitomi D; Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Matsuda T; Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Uede T; Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

PLoS One ; 9(12): e116210, 2014.

Article en En | MEDLINE | ID: mdl-25545242

Asunto(s)

Artritis Experimental/metabolismo; Colágeno Tipo II/inmunología; Integrinas/metabolismo; Metaloproteinasa 3 de la Matriz/metabolismo; Metaloproteinasa 7 de la Matriz/metabolismo; Osteopontina/química; Osteopontina/metabolismo; Secuencias de Aminoácidos; Secuencia de Aminoácidos; Animales; Anticuerpos/farmacología; Artritis Experimental/patología; Artritis Experimental/prevención & control; Células CHO; Movimiento Celular/efectos de los fármacos; Cricetinae; Cricetulus; Ligandos; Melanoma Experimental; Ratones; Datos de Secuencia Molecular; Células 3T3 NIH; Péptidos/metabolismo; Unión Proteica/efectos de los fármacos; Cicatrización de Heridas/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Integrinas / Metaloproteinasa 3 de la Matriz / Metaloproteinasa 7 de la Matriz / Colágeno Tipo II / Osteopontina Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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