Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years.
J Cyst Fibros
; 14(3): 361-9, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25563522
ABSTRACT
BACKGROUND:
We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources.METHODS:
Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy.RESULTS:
Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably.CONCLUSIONS:
CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Orofaringe
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Pseudomonas aeruginosa
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Infecciones por Pseudomonas
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ADN Bacteriano
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Líquido del Lavado Bronquioalveolar
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Fibrosis Quística
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Antibacterianos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
J Cyst Fibros
Año:
2015
Tipo del documento:
Article