A plakophilin-1 gene mutation in an egyptian family with ectodermal dysplasia-skin fragility syndrome.
Mol Syndromol
; 5(6): 304-6, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25565931
ABSTRACT
Ectodermal dysplasia-skin fragility syndrome (ED-SFS) is a rare genodermatosis caused by mutations in the PKP1 gene, encoding the desmosomal plaque protein plakophilin-1. Since its initial description in 1997, few individuals with this disorder have been reported to date. Here, we present the first Egyptian cases of ED-SFS, carrying a novel homozygous mutation in the PKP1 gene. Direct sequencing of the amplified DNA from the affected cases disclosed a G-to-T transversion at nucleotide position c.203-1 within intron 1 of PKP1 (c.203-1G>T). To the best of our knowledge, this mutation has not been previously described in the databases.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Syndromol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Egipto