Favourable effect of Eugenol on liver histology in acute cholestasis in rats after bile duct ligation.

BACKGROUND: Eugenol an essential oil found in clove was previously shown to have some anti-inflammatory properties. It also was shown to be linked to hepatoprotective effect. In this regard, we aimed to reveal the effect of eugenol on cholestatic liver disease. METHOD: Cholestatic liver disease model was established in 20 rats via bile duct ligation. Eugenol was administered and cytokine levels and liver histology after sacrifice were evaluated. RESULTS: Biliary ductular proliferation and neutropil infiltration were lower in eugenol-administered rats. CONCLUSION: Eugenol has a promising effect on liver histology in cholestatic liver disease (Tab. 1, Fig. 2, Ref. 16).