Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.

Vengrenyuk, Yuliya; Nishi, Hitoo; Long, Xiaochun; Ouimet, Mireille; Savji, Nazir; Martinez, Fernando O; Cassella, Courtney P; Moore, Kathryn J; Ramsey, Stephen A; Miano, Joseph M; Fisher, Edward A

Vengrenyuk, Yuliya; Nishi, Hitoo; Long, Xiaochun; Ouimet, Mireille; Savji, Nazir; Martinez, Fernando O; Cassella, Courtney P; Moore, Kathryn J; Ramsey, Stephen A; Miano, Joseph M; Fisher, Edward A.

Afiliación

Vengrenyuk Y; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Nishi H; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Long X; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Ouimet M; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Savji N; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Martinez FO; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Cassella CP; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Moore KJ; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Ramsey SA; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Miano JM; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu
Fisher EA; From the Marc and Ruti Bell Program in Vascular Biology, Division of Cardiology, Department of Medicine, NYU School of Medicine, New York (Y.V., H.N., M.O., N.S., C.P.C., K.J.M., E.A.F.); Center for Cardiovascular Sciences, Albany Medical College, NY (X.L.); Nuffield Department of Orthopaedics, Rheu

Arterioscler Thromb Vasc Biol ; 35(3): 535-46, 2015 Mar.

Article en En | MEDLINE | ID: mdl-25573853

Asunto(s)

Transdiferenciación Celular; Colesterol/metabolismo; Células Espumosas/metabolismo; MicroARNs/metabolismo; Músculo Liso Vascular/metabolismo; Miocitos del Músculo Liso/metabolismo; Proteínas Nucleares/metabolismo; Transactivadores/metabolismo; Animales; Aorta Torácica/metabolismo; Aorta Torácica/patología; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Aterosclerosis/genética; Aterosclerosis/metabolismo; Aterosclerosis/patología; Sitios de Unión; Linaje de la Célula; HDL-Colesterol/metabolismo; Técnicas de Cocultivo; Modelos Animales de Enfermedad; Células Espumosas/patología; Perfilación de la Expresión Génica/métodos; Regulación de la Expresión Génica; Humanos; Células Jurkat; Ratones Endogámicos C57BL; Ratones Noqueados; MicroARNs/genética; Músculo Liso Vascular/patología; Miocitos del Músculo Liso/patología; Necrosis; Proteínas Nucleares/genética; Análisis de Secuencia por Matrices de Oligonucleótidos; Fagocitosis; Fenotipo; Placa Aterosclerótica; Transducción de Señal; Proteína 2 de Unión a Elementos Reguladores de Esteroles/metabolismo; Factores de Tiempo; Transactivadores/genética; Transfección

Palabras clave

atherosclerosis; cholesterol; macrophages; plaque, atherosclerotic

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Transactivadores / Colesterol / Miocitos del Músculo Liso / MicroARNs / Transdiferenciación Celular / Células Espumosas / Músculo Liso Vascular Tipo de estudio: Prognostic_studies Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2015 Tipo del documento: Article

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