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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.
Merker, Matthias; Blin, Camille; Mona, Stefano; Duforet-Frebourg, Nicolas; Lecher, Sophie; Willery, Eve; Blum, Michael G B; Rüsch-Gerdes, Sabine; Mokrousov, Igor; Aleksic, Eman; Allix-Béguec, Caroline; Antierens, Annick; Augustynowicz-Kopec, Ewa; Ballif, Marie; Barletta, Francesca; Beck, Hans Peter; Barry, Clifton E; Bonnet, Maryline; Borroni, Emanuele; Campos-Herrero, Isolina; Cirillo, Daniela; Cox, Helen; Crowe, Suzanne; Crudu, Valeriu; Diel, Roland; Drobniewski, Francis; Fauville-Dufaux, Maryse; Gagneux, Sébastien; Ghebremichael, Solomon; Hanekom, Madeleine; Hoffner, Sven; Jiao, Wei-wei; Kalon, Stobdan; Kohl, Thomas A; Kontsevaya, Irina; Lillebæk, Troels; Maeda, Shinji; Nikolayevskyy, Vladyslav; Rasmussen, Michael; Rastogi, Nalin; Samper, Sofia; Sanchez-Padilla, Elisabeth; Savic, Branislava; Shamputa, Isdore Chola; Shen, Adong; Sng, Li-Hwei; Stakenas, Petras; Toit, Kadri; Varaine, Francis; Vukovic, Dragana.
Afiliación
  • Merker M; Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Blin C; 1] Laboratoire Biologie Intégrative des Population, Evolution Moléculaire, Ecole Pratique des Hautes Etudes, Paris, France. [2] Institut de Systématique, Evolution, Biodiversité, UMR-CNRS 7205, Muséum National d'Histoire Naturelle, Université Pierre et Marie Curie, Ecole Pratique des Hautes Etudes,
  • Mona S; 1] Laboratoire Biologie Intégrative des Population, Evolution Moléculaire, Ecole Pratique des Hautes Etudes, Paris, France. [2] Institut de Systématique, Evolution, Biodiversité, UMR-CNRS 7205, Muséum National d'Histoire Naturelle, Université Pierre et Marie Curie, Ecole Pratique des Hautes Etudes,
  • Duforet-Frebourg N; Université Joseph Fourier, Centre National de la Recherche Scientifique, Laboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques et Applications, Grenoble, France.
  • Lecher S; 1] INSERM U1019, Center for Infection and Immunity of Lille, Lille, France. [2] Centre National de la Recherche Scientifique, UMR 8204, Lille, France. [3] Université Lille Nord, Center for Infection and Immunity of Lille, Lille, France. [4] Institut Pasteur de Lille, Center for Infection and Immunit
  • Willery E; 1] INSERM U1019, Center for Infection and Immunity of Lille, Lille, France. [2] Centre National de la Recherche Scientifique, UMR 8204, Lille, France. [3] Université Lille Nord, Center for Infection and Immunity of Lille, Lille, France. [4] Institut Pasteur de Lille, Center for Infection and Immunit
  • Blum MG; Université Joseph Fourier, Centre National de la Recherche Scientifique, Laboratoire Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques et Applications, Grenoble, France.
  • Rüsch-Gerdes S; National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany.
  • Mokrousov I; Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, St. Petersburg, Russia.
  • Aleksic E; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia.
  • Allix-Béguec C; Genoscreen, Lille, France.
  • Antierens A; Medical Department, Médecins sans Frontières Switzerland, Geneva, Switzerland.
  • Augustynowicz-Kopec E; Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
  • Ballif M; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Barletta F; Instituto de Medicina Tropical Alexander von Humboldt, Molecular Epidemiology Unit-Tuberculosis, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Beck HP; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Barry CE; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
  • Bonnet M; Clinical Research Department, Epicentre, Paris, France.
  • Borroni E; Emerging Bacterial Pathogens Unit, San Raffaele Scientific Institute, Milan, Italy.
  • Campos-Herrero I; Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
  • Cirillo D; Emerging Bacterial Pathogens Unit, San Raffaele Scientific Institute, Milan, Italy.
  • Cox H; Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa.
  • Crowe S; 1] Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia. [2] Department of Infectious Diseases, Alfred Hospital, Melbourne, Victoria, Australia. [3] Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  • Crudu V; National Tuberculosis Reference Laboratory, Phthysiopneumology Institute, Chisinau, Republic of Moldova.
  • Diel R; Institute for Epidemiology, Schleswig-Holstein University Hospital, Kiel, Germany.
  • Drobniewski F; 1] Public Health England National Mycobacterial Reference Laboratory and Clinical Tuberculosis and Human Immunodeficiency Virus Group, Queen Mary's School of Medicine and Dentistry, London, UK. [2] Department of Infectious Diseases, Imperial College, London, UK.
  • Fauville-Dufaux M; Tuberculosis and Mycobacteria, Scientific Institute of Public Health, Brussels, Belgium.
  • Gagneux S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Ghebremichael S; Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
  • Hanekom M; Department of Science and Technology/National Research Foundation, Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council, Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University,
  • Hoffner S; Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden.
  • Jiao WW; Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
  • Kalon S; US Agency for International Development Quality Health Care Project, Bishkek, Kyrgyzstan.
  • Kohl TA; Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Kontsevaya I; Samara Oblast Tuberculosis Service, Samara, Russia.
  • Lillebæk T; Statens Serum Institute, International Reference Laboratory of Mycobacteriology, Copenhagen, Denmark.
  • Maeda S; Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
  • Nikolayevskyy V; 1] Public Health England National Mycobacterial Reference Laboratory and Clinical Tuberculosis and Human Immunodeficiency Virus Group, Queen Mary's School of Medicine and Dentistry, London, UK. [2] Department of Infectious Diseases, Imperial College, London, UK.
  • Rasmussen M; Statens Serum Institute, International Reference Laboratory of Mycobacteriology, Copenhagen, Denmark.
  • Rastogi N; World Health Organization Supranational Tuberculosis Reference Laboratory, Institut Pasteur de la Guadeloupe, Abymes, France.
  • Samper S; Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Sanchez-Padilla E; Clinical Research Department, Epicentre, Paris, France.
  • Savic B; Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Shamputa IC; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
  • Shen A; Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
  • Sng LH; Central Tuberculosis Laboratory, Department of Pathology, Singapore General Hospital, Singapore.
  • Stakenas P; Department of Immunology and Cell Biology, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
  • Toit K; Tartu University Hospital United Laboratories, Mycobacteriology, Tartu, Estonia.
  • Varaine F; Medical Department, Médecins sans Frontières, Paris, France.
  • Vukovic D; Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Nat Genet ; 47(3): 242-9, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25599400
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos