Outcomes of regenerative treatment with rhPDGF-BB and rhFGF-2 for periodontal intra-bony defects: a systematic review and meta-analysis.
J Clin Periodontol
; 42(3): 272-80, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25605424
ABSTRACT
BACKGROUND:
The aim was to evaluate the effects of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fibroblast growth factor-2 (rhFGF-2) on treating periodontal intra-bony defects, compared to the control (carrier alone).METHODS:
Electronic and hand searches were performed to identify eligible studies. The weighed mean differences of linear defect fill (LDF), probing depth (PD) reduction, clinical attachment level (CAL) gain and gingival recession (GR) were calculated using random effect meta-analysis.RESULTS:
The searches yielded 1018 articles, of which seven studies were included. Only one included study was considered at low risk of bias. The outcomes that reached statistical significance in comparison to carriers alone included LDF (0.95 mm, 95% CI 0.62-1.28 mm or 20.17%, 95% CI 11.81-28.54%) and CAL gain (0.34 mm, 95% CI 0.03-0.65 mm) for PDGF, and LDF (21.22%, 95% CI 5.82-36.61%) for FGF-2.CONCLUSIONS:
Within the limits of this review, rhPDGF-BB demonstrated significantly more LDF and CAL gain; rhFGF-2 resulted in significantly higher percentage of LDF.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pérdida de Hueso Alveolar
/
Factor 2 de Crecimiento de Fibroblastos
/
Regeneración Tisular Guiada Periodontal
/
Proteínas Proto-Oncogénicas c-sis
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
J Clin Periodontol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos