IQGAPs choreograph cellular signaling from the membrane to the nucleus.
Trends Cell Biol
; 25(3): 171-84, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25618329
ABSTRACT
Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1 have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been identified, implicating IQGAP1 as a critical integrator of cellular signaling pathways. Initial research established functions for IQGAP1 in cell-cell adhesion, cell migration, and cell signaling. Recent studies have revealed additional IQGAP1 binding partners, expanding the biological roles of IQGAP1. These include crosstalk between signaling cascades, regulation of nuclear function, and Wnt pathway potentiation. Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1. Summarized here are recent observations that enhance our understanding of IQGAP proteins in the integration of diverse signaling pathways.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Núcleo Celular
/
Proteínas Activadoras de GTPasa
/
Proteínas Activadoras de ras GTPasa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos