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Sarcopenia is a risk factor for elevated aminotransferase in men independently of body mass index, dietary habits, and physical activity.
Yoo, Ki Deok; Jun, Dae Won; Lee, Kang Nyeong; Lee, Hang Lak; Lee, Oh Young; Yoon, Byung Chul; Choi, Ho Soon.
Afiliación
  • Yoo KD; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Jun DW; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea. Electronic address: noshin@hanyang.ac.kr.
  • Lee KN; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Lee HL; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Lee OY; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Yoon BC; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Choi HS; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
Dig Liver Dis ; 47(4): 303-8, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25618554
BACKGROUND: Aminotransferase activity is a surrogate marker of liver injury showing strong correlations with obesity and metabolic syndrome. However, elevated aminotransferase activity is not uncommon in non-obese and non-alcoholic patients in clinical practice. AIM: To examine the relationship between sarcopenia and aminotransferase activity in a large population-based cohort. METHODS: Data from the Korean National Health and Nutrition Examinations were used. A total of 13,431 subjects were included. A whole-body dual X-ray absorptiometry scan was performed on each patient to measure total and regional muscle mass. Appendicular skeletal muscle mass indices were also obtained. RESULTS: The prevalence of sarcopenia was significantly higher in the group with elevated aminotransferase levels than in the normal liver enzyme group (males: 26.5% vs. 16.9%; females: 38.3% vs. 22.1%, p<0.05). The skeletal muscle index was negatively correlated with most cardiometabolic risk factors, including fasting glucose and cholesterol levels. The frequency of elevated aminotransferase increased in male patients with sarcopenia after adjusting for potential confounding factors including age, body mass index, fasting glucose level, dietary, and exercise habits. However, the correlation was no longer observed in women after adjusting for body mass index. CONCLUSION: Sarcopenia is a risk factor for elevated aminotransferase in men, independently of body mass index, dietary habits, and physical activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Músculo Esquelético / Conducta Alimentaria / Sarcopenia / Transaminasas / Hepatopatías / Actividad Motora Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Músculo Esquelético / Conducta Alimentaria / Sarcopenia / Transaminasas / Hepatopatías / Actividad Motora Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos