Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients.
Cancer Med
; 4(3): 354-62, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25619494
ABSTRACT
There is limited knowledge about the biological basis of racial/ethnic disparities in breast cancer outcomes. Aberrations in IGF signaling induced by obesity and other factors may contribute to these disparities. This study examines the expression profiles of the insulin-like growth factor (IGF)-axis proteins and the association with breast cancer survival across a multiethnic population. We examined the expression profiles of the IGF1, IGF1R, IGFBP2 (IGF-binding proteins), and IGFBP3 proteins in breast tumor tissue and their relationships with all-cause and breast cancer-specific survival up to 17 years postdiagnosis in a multiethnic series of 358 patients in Hawaii, USA. Native Hawaiians, Caucasians, and Japanese were compared. Covariates included demographic and clinical factors and ER/PR/HER2 (estrogen receptor/progesterone receptor/human epidermal growth factor receptor-2) status. In Native Hawaiian patients, IGFBP2 and IGFBP3 expression were each independently associated with overall and breast cancer mortality (IGFB2 HR(mort) = 10.96, 95% CI 2.18-55.19 and HR(mort) = 35.75, 95% CI 3.64-350.95, respectively; IGFBP3 HR(mort) = 5.16, 95% CI 1.27-20.94 and HR(mort) = 8.60, 95% CI 1.84-40.15, respectively). IGF1R expression was also positively associated with all-cause mortality in Native Hawaiians. No association of IGF-axis protein expression and survival was observed in Japanese or Caucasian patients. The interaction of race/ethnicity and IGFBP3 expression on mortality risk was significant. IGF-axis proteins may have variable influence on breast cancer progression across different racial/ethnic groups. Expression of binding proteins and receptors in breast tumors may influence survival in breast cancer patients by inducing aberrations in IGF signaling and/or through IGF-independent mechanisms. Additional studies to evaluate the role of the IGF-axis in breast cancer are critical to improve targeted breast cancer treatment strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Factor I del Crecimiento Similar a la Insulina
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Receptores de Somatomedina
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Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina
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Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Cancer Med
Año:
2015
Tipo del documento:
Article