Your browser doesn't support javascript.
loading
Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake.
Anderson, Courtney M; Kazantzis, Melissa; Wang, Jinshan; Venkatraman, Subramaniam; Goncalves, Renata L S; Quinlan, Casey L; Ng, Ryan; Jastroch, Martin; Benjamin, Daniel I; Nie, Biao; Herber, Candice; Van, An-Angela Ngoc; Park, Michael J; Yun, Dawee; Chan, Karen; Yu, Angela; Vuong, Peter; Febbraio, Maria; Nomura, Daniel K; Napoli, Joseph L; Brand, Martin D; Stahl, Andreas.
Afiliación
  • Anderson CM; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Kazantzis M; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Wang J; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Venkatraman S; Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA 94720, USA.
  • Goncalves RL; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Quinlan CL; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Ng R; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Jastroch M; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Benjamin DI; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Nie B; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Herber C; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Van AA; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Park MJ; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Yun D; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Chan K; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Yu A; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Vuong P; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Febbraio M; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
  • Nomura DK; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Napoli JL; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA.
  • Brand MD; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Stahl A; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address: astahl@berkeley.edu.
Cell Rep ; 10(4): 505-15, 2015 Feb 03.
Article en En | MEDLINE | ID: mdl-25620701
ABSTRACT
Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with CoQ has been successful as a therapy for patients with CoQ deficiency. However, which tissues depend on exogenous CoQ uptake as well as the mechanism by which CoQ is taken up by cells and the role of this process in BAT function are not well understood. Here, we report that the scavenger receptor CD36 drives the uptake of CoQ by BAT and is required for normal BAT function. BAT from mice lacking CD36 displays CoQ deficiency, impaired CoQ uptake, hypertrophy, altered lipid metabolism, mitochondrial dysfunction, and defective nonshivering thermogenesis. Together, these data reveal an important new role for the systemic transport of CoQ to BAT and its function in thermogenesis.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Ubiquinona / Antígenos CD36 Límite: Animals Idioma: En Revista: Cell Rep Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Ubiquinona / Antígenos CD36 Límite: Animals Idioma: En Revista: Cell Rep Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos