Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and ß-amyloid aggregation inhibitors with neuroprotective properties.

Guzior, Natalia; Bajda, Marek; Skrok, Miroslaw; Kurpiewska, Katarzyna; Lewinski, Krzysztof; Brus, Boris; Pislar, Anja; Kos, Janko; Gobec, Stanislav; Malawska, Barbara

Guzior, Natalia; Bajda, Marek; Skrok, Miroslaw; Kurpiewska, Katarzyna; Lewinski, Krzysztof; Brus, Boris; Pislar, Anja; Kos, Janko; Gobec, Stanislav; Malawska, Barbara.

Afiliación

Guzior N; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Bajda M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Skrok M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Kurpiewska K; Department of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
Lewinski K; Department of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
Brus B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Pislar A; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Kos J; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia; Department of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia.
Gobec S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. Electronic address: mfmalaws@cyf-kr.edu.pl.

Eur J Med Chem ; 92: 738-49, 2015 Mar 06.

Article en En | MEDLINE | ID: mdl-25621991

Asunto(s)

Acetilcolinesterasa/metabolismo; Péptidos beta-Amiloides/antagonistas & inhibidores; Bencilaminas/farmacología; Inhibidores de la Colinesterasa/farmacología; Fármacos Neuroprotectores/farmacología; Ftalimidas/farmacología; Agregado de Proteínas/efectos de los fármacos; Agregación Patológica de Proteínas/tratamiento farmacológico; Péptidos beta-Amiloides/metabolismo; Bencilaminas/síntesis química; Bencilaminas/química; Línea Celular Tumoral; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/química; Relación Dosis-Respuesta a Droga; Humanos; Modelos Moleculares; Estructura Molecular; Fármacos Neuroprotectores/síntesis química; Fármacos Neuroprotectores/química; Ftalimidas/síntesis química; Ftalimidas/química; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; Cholinesterase inhibitors; Multi-target-directed ligands; Neuroprotection; ß-amyloid aggregation inhibitors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ftalimidas / Acetilcolinesterasa / Bencilaminas / Inhibidores de la Colinesterasa / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Agregación Patológica de Proteínas / Agregado de Proteínas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Francia

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