Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia.
Mol Med Rep
; 11(6): 4039-46, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25625292
ABSTRACT
Paroxysmal or persistent tachycardia in pediatric patients is a common disease. Certain circulating microRNAs (miRNAs) have been associated with arrhythmia. The present study investigated miRNAs in the plasma of pediatric patients with tachycardia. Forty pediatric subjects were included retrospectively 24 with recurrent sustained tachycardia [seven cases of ventricular tachycardia (VT) and 17 cases of supraventricular tachycardia (SVT)] and 16 healthy controls. Circulating miR1 and miR133 in the plasma were detected by fluorescent quantitative polymerase chain reaction. miR1 levels were significantly decreased in the arrhythmia group compared with those in the controls (P=0.004) whilst miR133 expression levels were not significantly different between the two groups (P=0.456). Both miR1 and miR133 levels showed significant differences between the SVT and VT groups (P=0.004 and P=0.046, respectively), and a significant decrease in miR1 levels was observed in the SVT group as compared with the controls (P<0.001). No significant difference was observed in the expression levels of miR133. By contrast, miR133 levels were significantly increased in the VT group compared with those in the controls (P=0.024), whereas no statistically significant difference was observed in the expression levels of miR1. Receiver operating characteristic curves showed that 1/miR1 was significant for the evaluation of tachycardia. Additionally, miR1 produced enhanced sensitivity and specificity for the evaluation of SVT compared with miR133, whereas miR133 was a better marker to assess VT. This study demonstrated that miRNAs may be appropriate markers for pediatric tachycardia; miR1 levels were decreased in the arrhythmia group compared with those in the healthy controls. Furthermore, patients with SVT had lower miR1 expression levels while those with VT had higher miR133 expression levels.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taquicardia
/
MicroARNs
Límite:
Child
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Child, preschool
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Female
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Humans
/
Male
Idioma:
En
Revista:
Mol Med Rep
Año:
2015
Tipo del documento:
Article