Chromosome mapping and expression of a putative testis-determining gene in mouse.
Science
; 243(4887): 80-3, 1989 Jan 06.
Article
en En
| MEDLINE
| ID: mdl-2563174
ABSTRACT
Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger) encoding a multiple, potential zinc-binding, finger protein homologous to the candidate human testis-determining factor gene is reported. Four similar sequences were identified in Hind III-digested mouse genomic DNA. Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination. Polymerase chain reaction analysis suggests both Y loci are transcribed in adult testes. A 3.6-kb fragment was mapped to the X chromosome between the T16H and T6R1 translocation breakpoints, and a fourth (6.0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Análisis para Determinación del Sexo
/
Testículo
/
Transcripción Genética
/
Mapeo Cromosómico
/
Genes
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1989
Tipo del documento:
Article