Is there a dose response of dexamethasone as adjuvant for supraclavicular brachial plexus nerve block? A prospective randomized double-blinded clinical study.
J Clin Anesth
; 27(3): 237-42, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25637938
ABSTRACT
STUDY OBJECTIVE:
The study objective is to examine the analgesic effect of 3 doses of dexamethasone in combination with low concentration local anesthetics to determine the lowest effective dose of dexamethasone for use as an adjuvant in supraclavicular brachial plexus nerve block.DESIGN:
The design is a prospective randomized double-blinded clinical study.SETTING:
The setting is an academic medical center. PATIENTS The patients are 89 adult patients scheduled for shoulder arthroscopy.INTERVENTIONS:
All patients were randomly assigned into 1 of 4 treatment groups (i) bupivacaine, 0.25% 30 mL; (ii) bupivacaine, 0.25% 30 mL with 1-mg preservative-free dexamethasone; (iii) bupivacaine, 0.25% 30 mL with 2-mg preservative-free dexamethasone; and (iv) bupivacaine, 0.25% 30 mL with 4-mg preservative-free dexamethasone. All patients received ultrasound-guided supraclavicular brachial plexus nerve blocks and general anesthesia. MEASUREMENTS The measurements are the duration of analgesia and motor block. MAINRESULTS:
The median analgesia duration of supraclavicular brachial plexus nerve block with 0.25% bupivacaine was 12.1 hours; and 1-, 2-, or 4-mg dexamethasone significantly prolonged the analgesia duration to 22.3, 23.3, and 21.2 hours, respectively (P = .0105). Dexamethasone also significantly extended the duration of motor nerve block in a similar trend (P = .0247).CONCLUSION:
Low-dose dexamethasone (1-2 mg) prolongs analgesia duration and motor blockade to the similar extent as 4-mg dexamethasone when added to 0.25% bupivacaine for supraclavicular brachial plexus nerve block.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plexo Braquial
/
Dexametasona
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Analgesia
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Bloqueo Nervioso
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Clin Anesth
Asunto de la revista:
ANESTESIOLOGIA
Año:
2015
Tipo del documento:
Article