In vitro activity of carvacrol and thymol combined with antifungals or antibacterials against Pythium insidiosum.
J Mycol Med
; 25(2): e89-93, 2015 Jun.
Article
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| MEDLINE
| ID: mdl-25639921
ABSTRACT
We describe the in vitro activities of the combinations of carvacrol and thymol with antibiotics (azithromycin, clarithromycin, minocycline and tigecycline) and antifungal agents (amphotericin B, caspofungin, itraconazole and terbinafine) against 23 isolates of the oomycete Pythium insidiosum. The assays were based on the M38-A2 technique and checkerboard microdilution. Based on the mean FICI values, the main synergies observed were combinations of carvacrol+itraconazole and thymol+itraconazole (96%), thymol+clarithromycin (92%), carvacrol+clarithromycin (88%), thymol+minocycline (84%), carvacrol+minocycline (80%), carvacrol+azithromycin (76%), thymol+azithromycin (68%), carvacrol+tigecycline (64%) and thymol+tigecycline (60%). In conclusion, we found that combinations of carvacrol or thymol with these antimicrobial agents might provide effective alternative treatments for cutaneous pythiosis due to their synergistic interactions. Future in vivo experiments are needed to elucidate the safety and therapeutic potential of these combinations.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pythium
/
Timol
/
Monoterpenos
/
Antibacterianos
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
J Mycol Med
Año:
2015
Tipo del documento:
Article
País de afiliación:
Brasil