Which type of conditioning method protects the spinal cord from the ischemia-reperfusion injury in 24 hours?
Vascular
; 23(6): 614-21, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-25646020
ABSTRACT
OBJECTIVE:
This study was designed to test the effects of different types of preconditioning and postconditioning methods on spinal cord protection following aortic clamping.METHODS:
The animals (rabbits) were divided into sham-operated, ischemic preconditioning, remote ischemic preconditioning, simultaneous aortic and ischemic remote preconditioning, and ischemic postconditioning groups. After neurological evaluations, ultrastructural analysis and immunohistochemical staining for caspase-3 were evaluated after 24 h following ischemia.RESULTS:
The neurological outcomes of the remote ischemic preconditioning (4.2 ± 0.4) and ischemic postconditioning (4.6 ± 0.8) groups were significantly improved when compared with the ischemia group (2.2 ± 04). The immunohistochemical analysis revealed that the lowest percentage of apoptosis was in-group ischemic preconditioning at 12.5 ± 30.6%. In the comparison of intracellular edema in an ultrastructural analysis, the ischemic preconditioning and ischemic postconditioning groups had significantly lower values than the ischemia group.CONCLUSION:
The conditioning methods attenuate ischemia-reperfusion injury for spinal cord injury. Ischemic and remote preconditioning and also postconditioning methods are simple to perform and inexpensive.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta Abdominal
/
Médula Espinal
/
Arteria Axilar
/
Daño por Reperfusión
/
Precondicionamiento Isquémico
/
Isquemia de la Médula Espinal
/
Poscondicionamiento Isquémico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Vascular
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Turquía