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Femtosecond laser bone ablation with a high repetition rate fiber laser source.
Mortensen, Luke J; Alt, Clemens; Turcotte, Raphaël; Masek, Marissa; Liu, Tzu-Ming; Côté, Daniel C; Xu, Chris; Intini, Giuseppe; Lin, Charles P.
Afiliación
  • Mortensen LJ; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA ; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Alt C; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Turcotte R; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
  • Masek M; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Liu TM; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
  • Côté DC; Centre de Recherche Université Laval Robert-Giffard, Université Laval, Québec, QC G1J2G3, Canada.
  • Xu C; School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA.
  • Intini G; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA ; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA ; Giuseppe_Intini@hsdm.harvard.edu ; Co-corresponding authors.
  • Lin CP; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA ; Co-corresponding authors.
Biomed Opt Express ; 6(1): 32-42, 2015 Jan 01.
Article en En | MEDLINE | ID: mdl-25657872
ABSTRACT
Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos