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Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR.
Cannon, J; Fitzgerald, B; Seed, M; Agius, R; Jiwany, A; Cullinan, P.
Afiliación
  • Cannon J; Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK, j.cannon@rbht.nhs.uk.
  • Fitzgerald B; Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK.
  • Seed M; Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.
  • Agius R; Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.
  • Jiwany A; Department of Occupational Health, GlaxoSmithKline, Brentford, UK.
  • Cullinan P; Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK.
Occup Med (Lond) ; 65(3): 256-8, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25663384
ABSTRACT
We report occupational asthma and rhinitis in a formulation pharmacist, employed in the development of tafenoquine. Tafenoquine is a new anti-malarial drug in development; the pure drug substance has an asthma hazard index of zero and previously was not known to be a respiratory sensitizing agent. The implications of this finding for the refinement of quantitative structural analysis of asthmagenic chemicals are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad Cuantitativa / Industria Farmacéutica / Asma Ocupacional / Aminoquinolinas / Antimaláricos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Occup Med (Lond) Asunto de la revista: MEDICINA OCUPACIONAL Año: 2015 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad Cuantitativa / Industria Farmacéutica / Asma Ocupacional / Aminoquinolinas / Antimaláricos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Occup Med (Lond) Asunto de la revista: MEDICINA OCUPACIONAL Año: 2015 Tipo del documento: Article