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Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Wegert, Jenny; Ishaque, Naveed; Vardapour, Romina; Geörg, Christina; Gu, Zuguang; Bieg, Matthias; Ziegler, Barbara; Bausenwein, Sabrina; Nourkami, Nasenien; Ludwig, Nicole; Keller, Andreas; Grimm, Clemens; Kneitz, Susanne; Williams, Richard D; Chagtai, Tas; Pritchard-Jones, Kathy; van Sluis, Peter; Volckmann, Richard; Koster, Jan; Versteeg, Rogier; Acha, Tomas; O'Sullivan, Maureen J; Bode, Peter K; Niggli, Felix; Tytgat, Godelieve A; van Tinteren, Harm; van den Heuvel-Eibrink, Marry M; Meese, Eckart; Vokuhl, Christian; Leuschner, Ivo; Graf, Norbert; Eils, Roland; Pfister, Stefan M; Kool, Marcel; Gessler, Manfred.
Afiliación
  • Wegert J; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Ishaque N; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
  • Vardapour R; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Geörg C; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
  • Gu Z; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
  • Bieg M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
  • Ziegler B; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Bausenwein S; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Nourkami N; Department of Pediatric Oncology and Hematology, Saarland University Hospital, 66421 Homburg, Germany.
  • Ludwig N; Department of Human Genetics, Saarland University, 66421 Homburg, Germany.
  • Keller A; Department of Human Genetics, Saarland University, 66421 Homburg, Germany.
  • Grimm C; Theodor-Boveri-Institute/Biocenter, Biochemistry, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Kneitz S; Theodor-Boveri-Institute/Biocenter, Physiological Chemistry, Wuerzburg University, 97074 Wuerzburg, Germany.
  • Williams RD; UCL Institute of Child Health, London WC1N 1EH, UK.
  • Chagtai T; UCL Institute of Child Health, London WC1N 1EH, UK.
  • Pritchard-Jones K; UCL Institute of Child Health, London WC1N 1EH, UK.
  • van Sluis P; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • Volckmann R; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • Koster J; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • Versteeg R; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • Acha T; Unidad de Oncología Pediátrica, Hospital Materno-Infantil de Málaga, 29011 Malaga, Spain.
  • O'Sullivan MJ; National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, and Trinity College, Dublin 12, Ireland.
  • Bode PK; Department of Pediatric Hematology and Oncology, Children's University Hospital, 8032 Zurich, Switzerland.
  • Niggli F; Department of Pediatric Hematology and Oncology, Children's University Hospital, 8032 Zurich, Switzerland.
  • Tytgat GA; Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • van Tinteren H; Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1007 MB Amsterdam, the Netherlands.
  • van den Heuvel-Eibrink MM; Department of Pediatric Oncology, Erasmus MC-University Medical Center Rotterdam, 3000 CA Rotterdam, the Netherlands.
  • Meese E; Department of Human Genetics, Saarland University, 66421 Homburg, Germany.
  • Vokuhl C; Kiel Paediatric Cancer Registry, Christian Albrechts University, 24105 Kiel, Germany.
  • Leuschner I; Kiel Paediatric Cancer Registry, Christian Albrechts University, 24105 Kiel, Germany.
  • Graf N; Department of Pediatric Oncology and Hematology, Saarland University Hospital, 66421 Homburg, Germany.
  • Eils R; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department for Bioinformatics and Functional Genomics, Institute f
  • Pfister SM; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Gessler M; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg, Germany. Electronic address: gessler@biozentrum.uni-wuerzburg.de.
Cancer Cell ; 27(2): 298-311, 2015 Feb 09.
Article en En | MEDLINE | ID: mdl-25670083
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Tumor de Wilms / Proteínas de Homeodominio / Ribonucleasa III / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Tumor de Wilms / Proteínas de Homeodominio / Ribonucleasa III / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos