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Facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines.
Jia, Yan-Yan; Li, Xiao-Ye; Wang, Ping-An; Wen, Ai-Dong.
Afiliación
  • Jia YY; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Road 15, Xi'an 710032, China. xjyypharmacy@126.com.
  • Li XY; Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. lixiaoye@fmmu.edu.cn.
  • Wang PA; Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. ping_an1718@outlook.com.
  • Wen AD; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Road 15, Xi'an 710032, China. adwen@fmmu.edu.cn.
Molecules ; 20(2): 2922-30, 2015 Feb 11.
Article en En | MEDLINE | ID: mdl-25679051
Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Dipéptidos / Alcoholes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Dipéptidos / Alcoholes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza